Dataset Information


Homo sapiens

ABSTRACT: Altered expression of genes in WDR5 knockdown

ORGANISM(S): Homo sapiens  



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Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation.

Chen Xu X   Xie Weibin W   Gu Peng P   Cai Qingqing Q   Wang Bo B   Xie Yun Y   Dong Wen W   He Wang W   Zhong Guangzheng G   Lin Tianxin T   Huang Jian J  

Scientific reports 20150206

WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription; however, its role in bladder cancer remains largely unknown. Our study investigated the role of WDR5 in bladder cancer and demonstrated that WDR5 was upregulated in bladder cancer tissues, and elevated WDR5 protein levels positively correlated with advanced tumor stage and poor survival. Through gain or loss of function, we demonstrated that WDR5 promoted pro  ...[more]

Publication: 1/2

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