Dataset Information


Homo sapiens

ABSTRACT: Human CA2 ES cells undergoing stepwise differentiation to airway epithelium and challenged with TNFa and LPS

ORGANISM(S): Homo sapiens  



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Innate immune response of human pluripotent stem cell-derived airway epithelium.

McIntyre Brendan A S BA   Kushwah Rahul R   Mechael Rami R   Shapovalova Zoya Z   Alev Cantas C   Bhatia Mickie M  

Innate immunity 20140927 5

The acquisition of innate immune response is requisite to having bona fide differentiation of airway epithelium. Procedures developed to differentiate lung airway from human pluripotent stem cells (hPSCs) have demonstrated anecdotal evidence for innate immune response, but an in-depth exploration of response levels is lacking. Herein, using an established method of airway epithelial generation from hPSCs, we show that hPSC-derived epithelial cells are able to up-regulate expression of TNFα, IL8  ...[more]

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