Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA255405 | ENA |

REPOSITORIES: ENA

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Publications


Bevacizumab exerts anti-angiogenic effects in cancer patients by inhibiting vascular endothelial growth factor (VEGF). However, its use is still limited due to the development of resistance to the treatment. Such resistance can be regulated by various factors, although the underlying mechanisms remain incompletely understood. Here we show that bone marrow-derived fibrocyte-like cells, defined as alpha-1 type I collagen-positive and CXCR4-positive cells, contribute to the acquired resistance to b  ...[more]

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