Genomics

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ABSTRACT: Long noncoding RNAs as a novel component of the Myc transcriptional network

PROVIDER: PRJNA255406 | ENA |

REPOSITORIES: ENA

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Long noncoding RNAs as a novel component of the Myc transcriptional network.

Winkle Melanie M   van den Berg Anke A   Tayari Masoumeh M   Sietzema Jantine J   Terpstra Martijn M   Kortman Gertrud G   de Jong Debora D   Visser Lydia L   Diepstra Arjan A   Kok Klaas K   Kluiver Joost J  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150217 6


Myc is a well-known transcription factor with important roles in cell cycle, apoptosis, and cellular transformation. Long noncoding RNAs (lncRNAs) have recently emerged as an important class of regulatory RNAs. Here, we show that lncRNAs are a main component of the Myc-regulated transcriptional program using the P493-6 tetracycline-repressible myc model. We demonstrate that both Myc-induced mRNAs and lncRNAs are significantly enriched for Myc binding sites. In contrast to Myc-repressed mRNAs, My  ...[more]

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