Genomics

Dataset Information

118

Cricetulus griseus


ABSTRACT: Mre11 suppresses replication stress and gene amplification proficiency

ORGANISM(S): Cricetulus griseus  

PROVIDER: PRJNA255418 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Replication fork integrity and intra-S phase checkpoint suppress gene amplification.

Kondratova Anna A   Watanabe Takaaki T   Marotta Michael M   Cannon Matthew M   Segall Anca M AM   Serre David D   Tanaka Hisashi H  

Nucleic acids research 20150211 5


Gene amplification is a phenotype-causing form of chromosome instability and is initiated by DNA double-strand breaks (DSBs). Cells with mutant p53 lose G1/S checkpoint and are permissive to gene amplification. In this study we show that mammalian cells become proficient for spontaneous gene amplification when the function of the DSB repair protein complex MRN (Mre11/Rad50/Nbs1) is impaired. Cells with impaired MRN complex experienced severe replication stress and gained substrates for gene ampl  ...[more]

Similar Datasets

| PRJNA330832 | ENA
| PRJNA214684 | ENA
| PRJNA143557 | ENA
| PRJNA90785 | ENA
| PRJNA105311 | ENA
| PRJNA105207 | ENA
| PRJNA159471 | ENA
| PRJNA322598 | ENA
| PRJNA305185 | ENA
| PRJNA256330 | ENA