Genomics

Dataset Information

0

Danio rerio


ABSTRACT: Identification and characterization of androgen responsive biomarker genes in zebrafish embryos

ORGANISM(S): Danio rerio  

PROVIDER: PRJNA255434 | ENA |

REPOSITORIES: ENA

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Publications

Identification and Characterization of Androgen-Responsive Genes in Zebrafish Embryos.

Fetter Eva E   Smetanová Soňa S   Baldauf Lisa L   Lidzba Annegret A   Altenburger Rolf R   Schüttler Andreas A   Scholz Stefan S  

Environmental science & technology 20150909 19


Responsive genes for fish embryos have been identified so far for some endocrine pathways but not for androgens. Using transcriptome analysis and multiple concentration-response modeling, we identified putative androgen-responsive genes in zebrafish embryos exposed to 0.05-5000 nM 11-ketotestosterone for 24 h. Four selected genes with sigmoidal concentration-dependent expression profiles (EC50 = 6.5-30.0 nM) were characterized in detail. The expression of cyp2k22 and slco1f4 was demonstrated in  ...[more]

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