Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The effects of leptin deficiency on cold-induced energy expenditure

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA255493 | ENA |

REPOSITORIES: ENA

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Publications

Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status.

Jaroslawska Julia J   Chabowska-Kita Agnieszka A   Kaczmarek Monika M MM   Kozak Leslie P LP  

PLoS genetics 20150612 6


The mechanism by which mice, exposed to the cold, mobilize endogenous or exogenous fuel sources for heat production is unknown. To address this issue we carried out experiments using 3 models of obesity in mice: C57BL/6J+/+ (wild-type B6) mice with variable susceptibility to obesity in response to being fed a high-fat diet (HFD), B6. Ucp1-/- mice with variable diet-induced obesity (DIO) and a deficiency in brown fat thermogenesis and B6. Lep-/- with defects in thermogenesis, fat mobilization and  ...[more]

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