Dataset Information


Homo sapiens

ABSTRACT: Accurate prediction and validation of response to endocrine therapy in breast cancer

ORGANISM(S): Homo sapiens  



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Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.

Turnbull Arran K AK   Arthur Laura M LM   Renshaw Lorna L   Larionov Alexey A AA   Kay Charlene C   Dunbier Anita K AK   Thomas Jeremy S JS   Dowsett Mitch M   Sims Andrew H AH   Dixon J Michael JM  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20150601 20

PURPOSE:Aromatase inhibitors (AIs) have an established role in the treatment of breast cancer. Response rates are only 50% to 70% in the neoadjuvant setting and lower in advanced disease. Accurate biomarkers are urgently needed to predict response in these settings and to determine which individuals will benefit from adjuvant AI therapy. PATIENTS AND METHODS:Pretreatment and on-treatment (after 2 weeks and 3 months) biopsies were obtained from 89 postmenopausal women who had estrogen receptor-al  ...[more]

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