Genomics

Dataset Information

353

Drosophila melanogaster


ABSTRACT: Trans-generationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing [Rhino RNA-seq]

ORGANISM(S): Drosophila melanogaster  

PROVIDER: PRJNA256130 | ENA |

REPOSITORIES: ENA

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Publications

Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing.

Le Thomas Adrien A   Stuwe Evelyn E   Li Sisi S   Du Jiamu J   Marinov Georgi G   Rozhkov Nikolay N   Chen Yung-Chia Ariel YC   Luo Yicheng Y   Sachidanandam Ravi R   Toth Katalin Fejes KF   Patel Dinshaw D   Aravin Alexei A AA  

Genes & development 20140801 15


Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the genomic regions that give rise to piRNAs, the so-called piRNA clusters, are transcribed to generate long precursor molecules that are processed into mature piRNAs. How genomic regions that give rise to piRNA precursor transcripts are differentiated from the rest of the genome and how these transcripts are specifically  ...[more]

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