Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Gene expression data of Kas-/- mouse emobryonic fibroblasts transfected with KRAS siRNAs

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA256309 | ENA |

REPOSITORIES: ENA

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Publications


RNAi is a powerful tool for target identification and can lead to novel therapies for pharmacologically intractable targets such as KRAS. RNAi therapy must combine potent siRNA payloads with reliable in vivo delivery for efficient target inhibition. We used a functional "Sensor" assay to establish a library of potent siRNAs against RAS pathway genes and to show that they efficiently suppress their targets at low dose. This reduces off-target effects and enables combination gene knockdown. We adm  ...[more]

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