Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Gene expression profiling of Lgr5-creERT2/PIK3CA H1047R and K8-creERT2/PIK3CA H1047R-evoked mammary tumors

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA256962 | ENA |

REPOSITORIES: ENA

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Publications


The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative potential. A key issue in breast cancer biology is the effect of genomic lesions in specific mammary cell lineages on tumour heterogeneity and progression. The impact of transforming events on fate conversion in cancer cells of origin and thus their contribution to tumour heterogeneity r  ...[more]

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