Dataset Information


Drosophila melanogaster

ABSTRACT: Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

ORGANISM(S): Drosophila melanogaster  



Dataset's files

Action DRS
SRR1531530.fastq.gz Fastqsanger.gz
SRR1531523.fastq.gz Fastqsanger.gz
SRR1531524.fastq.gz Fastqsanger.gz
SRR1531525.fastq.gz Fastqsanger.gz
SRR1531526.fastq.gz Fastqsanger.gz
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Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.

Herz Hans-Martin HM   Morgan Marc M   Gao Xin X   Jackson Jessica J   Rickels Ryan R   Swanson Selene K SK   Florens Laurence L   Washburn Michael P MP   Eissenberg Joel C JC   Shilatifard Ali A  

Science (New York, N.Y.) 20140801 6200

Histone H3 lysine(27)-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes and developmental perturbations. Similarly, an H3K9M mutant depletes H3K9 methylation levels and suppresses position-effect variegation in various  ...[more]

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