Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensitive (SS) rat and SS13BN consomic rat. SS13BN rats are derived from introgression of chromosome 13 from Brown Norway (BN) rat into the SS genetic background.
Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensitive (SS) rat and SS13BN consomic rat. SS13BN rats are derived from introgression of chromosome 13 from the Brown Norway (BN) rat into the SS genetic background.
Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensitive (SS) rat and SS7BN consomic rat. SS7BN rats are derived from introgression of chromosome 7 from the Brown Norway (BN) rat into the SS genetic background.
Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensitive (SS) rat and SS7BN consomic rat. SS7BN rats are derived from introgression of chromosome 7 from the Brown Norway (BN) rat into the SS genetic background.
Project description:Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes associated with salt-sensitive hypertension by utilizing a custom, known-gene cDNA microarray to compare the mRNA expression profiles in the renal medulla (a tissue playing a pivotal role in long-term blood pressure regulation) of SS/Mcw and SSBN13 rats on either low-salt (0.4% NaCl) or high-salt (4% NaCl, 2 wk) diets. Keywords: Dahl S rat; blood pressure; kidney; consomic rats
Project description:Chromosome 2 introgression from normotensive Brown Norway (BN) rats into hypertensive Dahl salt-sensitive (SS) background (consomic S2B) reduced blood pressure (BP) and vascular inflammation under normal salt diet (NSD). We hypothesized that BN chromosome 2 contains anti-inflammatory genes that could reduce BP elevation and vascular inflammation in rats fed NSD and high salt diet (HSD). We used chromosome 2 fragment substitutions to map chromosome 2 portion associated with vascular inflammation changes and next generation sequencing (NGS) to profile messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) in thoracic descending aorta of SS and congenic rats fed NSD or HSD.
Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS4BN consomic rat. SS4BN rats are derived from introgression of chromosome 4 from Brown Norway (BN) rat into the genetic background.
Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS11BN consomic rat. SS11BN rats are derived from introgression of chromosome 11 from Brown Norway (BN) rat into the SS genetic background.
Project description:Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS13BN cosomic rat. SS13BN rats are derived from introgression of chromosome 13 from the Brown Norway (BN) rat into the SS genetic background.
Project description:The objective of this study was to profile circular RNAs (circRNAs) in rat genetic models of cardiovascular and renal disease. Renal profiles were obtained from the Dahl Salt-Sensitive rat (S), the Dahl Salt-Resistant rat (R), the Spontaneously Hypertensive Rat (SHR) and the Wistar Kyoto rat (WKY).
