Caenorhabditis elegans
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA257641 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Dietary restriction in Caenorhabditis elegans
| PRJNA103573 | ENA
Project description:RNA-Seq analysis of dietary restriction and loss of SEK-1 in C. elegans
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Project description:Whole genome microRNA expression profiling of long-lived daf-2(e1370) mutant in C. elegans at young adult stage
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Project description:C.elegans time course study on dietary restriction and aging
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Project description:MicroRNA-Directed siRNA Biogenesis in Caenorhabditis elegans
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Project description:Dietary restriction (DR) is the most effective and reproducible intervention to extend lifespan in divergent species1. In mammals, two regimens of DR, intermittent fasting (IF) and caloric restriction (CR), have proven to extend lifespan and reduce the incidence of age-related disorders2. An important characteristic of IF is that it can increase lifespan, even when there is little or no overall decrease in calorie intake2. The molecular mechanisms underlying IF-induced longevity, however, remain largely unknown. Here we establish an IF regimen that effectively extends the lifespan of Caenorhabditis elegans, and show that a nutrient-related signalling molecule, the low molecular weight GTPase Cel-Rheb, has a dual role in lifespan regulation; Cel-Rheb is required for the IF-induced longevity, whereas inhibition of Cel-Rheb mimics the CR effects. We also show that Cel-Rheb exerts its effects in part via the insulin/IGF-like signalling effector DAF-16 in IF, and that Cel-Rheb is required for fasting-induced nuclear translocation of DAF-16. We find that HSP-12.6, a DAF-16 target, functions to mediate the IF-induced longevity. Furthermore, our analyses demonstrate that most of fasting-induced upregulated genes require Cel-Rheb function for their induction, and that Cel-Rheb/Cel-TOR signalling is required for the fasting-induced downregulation of an insulin-like peptide, INS-7. These findings identify the essential role of signalling via Cel-Rheb in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway.
2008-12-15 | GSE9682 | GEO
Project description:Genome-wide expression analysis during aging in C. elegans
| PRJNA127309 | ENA
Project description:Expression data from synchronized L4 C. elegans during starvation
| PRJNA116677 | ENA
Project description:Expression data from C. elegans during L3 and L3-lethargus
| PRJNA198533 | ENA