Project description:Individual differences in basal leukocyte gene expression profiles as a function of Big 5 personality dimensions Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 119 healthy adults measured for the 5 major dimensions of human personality (Neuroticism, Extraversion, Openness, Agreeableness, Conscientiousness) using the NEO-FFI 60-item personality inventory. Personality measures are z-score standardized. Analyses control for major demographic characteristics (age, sex, Caucasian vs Non-Caucasian race) as well as Body Mass Index (BMI), smoking (CigDay), alcohol consumption (AlcDay), and physical activity (ExerDay, hours per day). Additional secondary analyses controlled for the presence of minor physical symptoms (MinorSymptom, e.g.,hayfever, headache), medication use (BirthControl, Antidepressant, OtherMedication), and negative affective states (NegativeAffect, standardized values of PANAS Negative Affect scale). Experiment type: Risk prediction
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
Project description:Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression.
