Genomics

Dataset Information

176

Homo sapiens


ABSTRACT: Resetting Transcription Factor Control Circuitry Towards Ground State Pluripotency In Human

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA259876 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


Current human pluripotent stem cells lack the transcription factor circuitry that governs the ground state of mouse embryonic stem cells (ESC). Here, we report that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the network and reset the human pluripotent state. Inhibition of ERK and protein kinase C sustains a transgene-independent rewired state. Reset cells self-renew continuously without ERK signaling, are phenotypically stable, and are kary  ...[more]

Similar Datasets

2014-09-10 | E-GEOD-60945 | ArrayExpress
2013-01-18 | E-GEOD-42616 | ArrayExpress
2011-10-03 | E-GEOD-32581 | ArrayExpress
2011-10-04 | GSE32581 | GEO
2014-06-04 | E-MTAB-2366 | ArrayExpress
2014-06-04 | E-MTAB-2365 | ArrayExpress
2013-01-18 | E-GEOD-42580 | ArrayExpress
2014-07-16 | E-GEOD-59434 | ArrayExpress
| PRJNA354616 | ENA
2015-12-07 | E-MTAB-4068 | ArrayExpress