Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: Genome-wide Definition of Promoter and Enhancer Usage During Neural Induction of Human Embryonic Stem Cells [CAGE-seq]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA260622 | ENA |

REPOSITORIES: ENA

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Publications


Genome-wide mapping of transcriptional regulatory elements is an essential tool for understanding the molecular events orchestrating self-renewal, commitment and differentiation of stem cells. We combined high-throughput identification of transcription start sites with genome-wide profiling of histones modifications to map active promoters and enhancers in embryonic stem cells (ESCs) induced to neuroepithelial-like stem cells (NESCs). Our analysis showed that most promoters are active in both ce  ...[more]

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