Dataset Information


Homo sapiens

ABSTRACT: HOTAIR lentiviral infected prostate cancer cells

ORGANISM(S): Homo sapiens  



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LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.

Zhang Ali A   Zhao Jonathan C JC   Kim Jung J   Fong Ka-Wing KW   Yang Yeqing Angela YA   Chakravarti Debabrata D   Mo Yin-Yuan YY   Yu Jindan J  

Cell reports 20150924 1

Understanding the mechanisms of androgen receptor (AR) activation in the milieu of low androgen is critical to effective treatment of castration-resistant prostate cancer (CRPC). Here, we report HOTAIR as an androgen-repressed lncRNA, and, as such, it is markedly upregulated following androgen deprivation therapies and in CRPC. We further demonstrate a distinct mode of lncRNA-mediated gene regulation, wherein HOTAIR binds to the AR protein to block its interaction with the E3 ubiquitin ligase MD  ...[more]

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