Dataset Information


Homo sapiens

ABSTRACT: Expression data in NK150460 treated breast cancer cell lines

ORGANISM(S): Homo sapiens  



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A novel compound, NK150460, exhibits selective antitumor activity against breast cancer cell lines through activation of aryl hydrocarbon receptor.

Fukasawa Kazuteru K   Kagaya Shigehide S   Maruyama Sakiko S   Kuroiwa Shunsuke S   Masuda Kuniko K   Kameyama Yoshio Y   Satoh Yoshitaka Y   Akatsu Yuichi Y   Tomura Arihiro A   Nishikawa Kiyohiro K   Horie Shigeo S   Ichikawa Yuh-ichiro Y  

Molecular cancer therapeutics 20141218 2

Antiestrogen agents are commonly used to treat patients with estrogen receptor (ER)-positive breast cancer. Tamoxifen has been the mainstay of endocrine treatment for patients with early and advanced breast cancer for many years. Following tamoxifen treatment failure, however, there are still limited options for subsequent hormonal therapy. We discovered a novel compound, NK150460, that inhibits 17β-estradiol (E2)-dependent transcription without affecting binding of E2 to ER. Against our expecta  ...[more]

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