Genomics

Dataset Information

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ABSTRACT: Treatment of C3H/HeJ grafted mice with baricitinib

PROVIDER: PRJNA261447 | ENA |

REPOSITORIES: ENA

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Alopecia areata (AA) is an autoimmune disease resulting in hair loss with devastating psychosocial consequences. Despite its high prevalence, there are no FDA-approved treatments for AA. Prior studies have identified a prominent interferon signature in AA, which signals through JAK molecules.A patient with AA was enrolled in a clinical trial to examine the efficacy of baricitinib, a JAK1/2 inhibitor, to treat concomitant CANDLE syndrome. In vivo, preclinical studies were conducted using the C3H/  ...[more]

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