Dataset Information


Homo sapiens

ABSTRACT: Primary CNS lymphoma B cell receptors recognize CNS proteins

ORGANISM(S): Homo sapiens  



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Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins.

Montesinos-Rongen Manuel M   Purschke Frauke G FG   Brunn Anna A   May Caroline C   Nordhoff Eckhard E   Marcus Katrin K   Deckert Martina M  

Journal of immunology (Baltimore, Md. : 1950) 20150626 3

Primary lymphoma of the CNS (PCNSL) is a diffuse large B cell lymphoma confined to the CNS. To elucidate its peculiar organ tropism, we generated recombinant Abs (recAbs) identical to the BCR of 23 PCNSLs from immunocompetent patients. Although none of the recAbs showed self-reactivity upon testing with common autoantigens, they recognized 1547 proteins present on a large-scale protein microarray, indicating polyreactivity. Interestingly, proteins (GRINL1A, centaurin-α, BAIAP2) recognized by the  ...[more]

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