Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Gene expression analysis of CD11c+ splenic DCs.

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA261454 | ENA |

REPOSITORIES: ENA

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Publications


Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. Here we find that Atg16L1 deficiency leads to an exacerbated graft-versus-host disease (GVHD) in a mouse model of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Atg16L1-deficient allo-HSCT recipients with GVHD displayed increased T cell proliferation due to increased dendritic cell (DC) numbers and  ...[more]

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