Genomics

Dataset Information

176

Caenorhabditis elegans


ABSTRACT: TDP-1, the C. elegans ortholog of TDP-43, limits the accumulation of double stranded RNA

ORGANISM(S): Caenorhabditis elegans  

PROVIDER: PRJNA261532 | ENA |

REPOSITORIES: ENA

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Publications


Caenorhabditis elegans mutants deleted for TDP-1, an ortholog of the neurodegeneration-associated RNA-binding protein TDP-43, display only mild phenotypes. Nevertheless, transcriptome sequencing revealed that many RNAs were altered in accumulation and/or processing in the mutant. Analysis of these transcriptional abnormalities demonstrates that a primary function of TDP-1 is to limit formation or stability of double-stranded RNA. Specifically, we found that deletion of tdp-1: (1) preferentially  ...[more]

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