Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA261548 | ENA |

REPOSITORIES: ENA

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Publications

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs.

Shrestha Sharad S   Yang Kai K   Wei Jun J   Karmaus Peer W F PW   Neale Geoffrey G   Chi Hongbo H  

Proceedings of the National Academy of Sciences of the United States of America 20140930 41


Memory CD8(+) T cells are an essential component of protective immunity. Signaling via mechanistic target of rapamycin (mTOR) has been implicated in the regulation of the differentiation of effector and memory T cells. However, little is understood about the mechanisms that control mTOR activity, or the effector pathways regulated by mTOR. We describe here that tuberous sclerosis 1 (Tsc1), a regulator of mTOR signaling, plays a crucial role in promoting the differentiation and function of memory  ...[more]

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