Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Effects of PLEKHA7 depletion on miRNA expression

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA261550 | ENA |

REPOSITORIES: ENA

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Publications


E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at the apical zonula adherens (ZA), defined by the p120 partner PLEKHA7 and a non-nuclear subset of the core microprocessor components DROSHA and DGCR8, and one growth promoting at basolatera  ...[more]

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