Project description:Lhx5 mutant mouse embryos show loss of a neuronal nucleus of the brain called the mamillary body and essential for the formation of memories. We wanted to identify the genes that are responsible for the normal development of the mammillary body. Therefore, we used microarray experiments to identify the genes that show a changed expression in the Lhx5 mutant mammillary neuroepithelium in comparison to the wild type.
Project description:Lhx5 mutant mouse embryos show loss of a neuronal nucleus of the brain, called the mammillary body and essential for memory. We found out that this is caused by a loss of appropriate specification of mammillary neurons and we identified in a microarray study downstream targets responsible for the observed phenotype. Here we wanted to find out which of our identified targets are under direct control of Lhx5.
