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Rattus norvegicus albus breed:Selectively bred alcohol-preferring (P) and nonpreferring (NP)

ABSTRACT: RNAseq of selectively bred alcohol-preferring (P) and nonpreferring (NP) rats

PROVIDER: PRJNA262040 | ENA |

REPOSITORIES: ENA

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Comparison of whole brain expression data between selectively bred P and NP, alcohol naïve rats

2011-04-19 | GSE15764 | GEO

Comparison of whole brain expression data between selectively bred P and NP, alcohol naïve rats

Project description:Gene expression was analyzed in brains of 4 male selectively-bred alcohol-preferring (P) rats (generation 63) and 3 male alcohol non-preferring (NP) rats (generation 62) that were obtained from Dr. Richard L. Bell, Indiana University School of Medicine, Indianapolis, IN. These rats had never been exposed to alcohol. Individual rats from each group were hybridized separately to individual arrays (one array per rat). No duplicates are present. Originally, four NP samples were analyzed, but one was dropped because of quality control standards.

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Project description:The objective of this study was to determine common innate differences in gene expression in the nucleus accumbens shell among the selectively bred (a) alcohol-preferring (P) vs. alcohol-non-preferring (NP) rats: (b) high-alcohol-drinking (HAD) vs. low-alcohol-drinking (LAD) rats (both replicates); (c) ALKO alcohol (AA) vs. nonalcohol (ANA) rats; and (d) Sardinian alcohol-preferring (sP) vs. alcohol-nonpreferring (sNP) rats. Comparison of Differences in Gene Expression in the Nucleus Accumbens Shell of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption.

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Project description:The objective of this study was to determine common innate differences in gene expression in the Central Nucleus of the Amygdala (CeA) among the selectively bred (a) alcohol-preferring (P) vs. alcohol-non-preferring (NP) rats: (b) high-alcohol-drinking (HAD) vs. low-alcohol-drinking (LAD) rats (both replicates); (c) ALKO alcohol (AA) vs. nonalcohol (ANA) rats; and (d) Sardinian alcohol-preferring (sP) vs. alcohol-nonpreferring (sNP) rats. Comparison of Differences in Gene Expression in the Central Nucleus of the Amygdala (CeA) of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption.

2012-07-31 | E-GEOD-31708 | biostudies-arrayexpress

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2012-07-31 | E-GEOD-31695 | biostudies-arrayexpress

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2012-07-31 | E-GEOD-31709 | biostudies-arrayexpress

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