Project description:Whole Genome Metabolism of "Halothiobacillus neapolitanus (strain ATCC 23641 / c2)"
This is a whole genome metabolism model of Halothiobacillus neapolitanus (strain ATCC 23641 / c2).
This model has been automatically generated by the SuBliMinaL Toolbox
and libAnnotationSBML using information coming from from KEGG (release 66, April 2013, accessed via the resource's web services interface) and, where relevant, augmented with metabolic pathway information extracted from MetaCyc (version 17.0, March 2013).
This model has been produced by the path2models
project and is currently hosted on BioModels Database
and identified by: BMID000000140826
Other models with the same genus include BMID000000006004 BMID000000006005 BMID000000006006 BMID000000006007 BMID000000006008 BMID000000006009 BMID000000006010 BMID000000006011 BMID000000006012 BMID000000006013 BMID000000006014 BMID000000006015 BMID000000006016 BMID000000006017 BMID000000006018 BMID000000006019 BMID000000052257 BMID000000052258 BMID000000052259 BMID000000052260 BMID000000052261 BMID000000052262 BMID000000052263 BMID000000052264 BMID000000052265 BMID000000052266 BMID000000052267 BMID000000052268 BMID000000052269 BMID000000052270 BMID000000052271 BMID000000052272 BMID000000052273 BMID000000052274 BMID000000052275 BMID000000052276 BMID000000052277 BMID000000052278 BMID000000052279 BMID000000052280 BMID000000052281 BMID000000052282 BMID000000052283 BMID000000052284 BMID000000052285 BMID000000052286 BMID000000052287 BMID000000052288 BMID000000052289 BMID000000052290 BMID000000052291 BMID000000052292 BMID000000052293 BMID000000052294 BMID000000052295 BMID000000052296 BMID000000052297 BMID000000052298 BMID000000052299 BMID000000052300 BMID000000052301 BMID000000052302 BMID000000052303 BMID000000052304 BMID000000052305 BMID000000052306 BMID000000052307 BMID000000052308 BMID000000052309 BMID000000052310 BMID000000052311 BMID000000052312 BMID000000052313 BMID000000052314 BMID000000052315 BMID000000052316 BMID000000052317 BMID000000052318 BMID000000052319 BMID000000052320 BMID000000052321 BMID000000052322 BMID000000052323 BMID000000052324 BMID000000052325 BMID000000052326 BMID000000052327 BMID000000052328 BMID000000052329 BMID000000052330 BMID000000052331 .
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication
for more information.
Project description:Side populations have recently been identified in ovarian cancers and may play an important role in post treatment relapse and resistance to chemotherapeutic drugs. In this study, we aimed to identify the differential expression between IGROV1 SP and NSP on Affymetrix HG-U133plus2 microarrays. We found ovarian tumour SP cells frequently over-express the multi-drug resistance associated P-glycoprotein (ABCB1) by Rank Product (FDR<0.05), and by geneset enrichment analysis, embryonic stem cell-associated ‘NOS’ signature (Notch/Oct4/Sox2 regulated genes) and Polycomb Repressive Complex 2 (PRC2) genes were over-expressed, while PRC2-repressed target genes were significantly under-expressed in the SP from ovarian cell lines compared to non-SP (FDR<10-4). Overall design: Cells were isolated using Hoechst 33342 cell sorting without other treatment. The experiment was carried out in triplicates: 3 SP samples and 3 non-SP samples
Project description:Corneal epithelial stem cells reside in the limbus that is the transitional zone between the cornea and conjunctiva, and are essential to maintain the homeostasis of corneal epithelium. However, their characterization is poorly understood. Therefore, we constructed gene expression profiles of limbal epithelial SP and non-SP cell using RNA-sequencing. As a result, limbal epithelial SP cells have immature cell phenotypes with endothelial/mesenchymal cell markers, while limbal epithelial non-SP cells have epithelial progenitor cell markers. Overall design: Examination of rabbit limbal epithelial SP and non-SP cells