Dataset Information


Rattus norvegicus

ABSTRACT: S100 calcium-binding proteins A8/A9 initiate the early inflammatory program in injured peripheral nerve

ORGANISM(S): Rattus norvegicus  



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The calcium-binding proteins S100A8 and S100A9 initiate the early inflammatory program in injured peripheral nerves.

Chernov Andrei V AV   Dolkas Jennifer J   Hoang Khang K   Angert Mila M   Srikrishna Geetha G   Vogl Thomas T   Baranovskaya Svetlana S   Strongin Alex Y AY   Shubayev Veronica I VI  

The Journal of biological chemistry 20150319 18

To shed light on the early immune response processes in severed peripheral nerves, we performed genome-wide transcriptional profiling and bioinformatics analyses of the proximal (P, regenerating) and distal (D, degenerating) nerve stumps on day 1 in the sciatic nerve axotomy model in rats. Multiple cell death-related pathways were activated in the degenerating D stump, whereas activation of the cytoskeletal motility and gluconeogenesis/glycolysis pathways was most prominent in the P stump of the  ...[more]

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