Genomics

Dataset Information

0

Mus musculus


ABSTRACT: A dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA264053 | ENA |

REPOSITORIES: ENA

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Publications


Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Proteomic studies identified K217 as the FXR acetylation site in diet-induced obese mice. In vivo studies utilizing acetylation-mimic and acetylation-defective K217 mutants and gene expression profiling r  ...[more]

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