Genomics

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Global gene expression profiling human and Chimpanzee induced pluripotent stem (iPS) cell


ABSTRACT: Global gene expression profiling human and Chimpanzee induced pluripotent stem (iPS) cell

PROVIDER: PRJNA264461 | ENA |

REPOSITORIES: ENA

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Induced pluripotent stem cells (iPSCs) are potentially valuable cell sources for disease models and future therapeutic applications; however, inefficient generation and the presence of integrated transgenes remain as problems limiting their current use. Here, we developed a new Sendai virus vector, TS12KOS, which has improved efficiency, does not integrate into the cellular DNA, and can be easily eliminated. TS12KOS carries KLF4, OCT3/4, and SOX2 in a single vector and can easily generate iPSCs  ...[more]

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