Genomics

Dataset Information

2

Homo sapiens


ABSTRACT: Next generation sequencing reveals microRNA isoforms in liver cirrhosis and hepatocellular carcinoma

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA266511 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR1642950.fastq.gz Fastqsanger.gz
SRR1642960.fastq.gz Fastqsanger.gz
SRR1642970.fastq.gz Fastqsanger.gz
SRR1642980.fastq.gz Fastqsanger.gz
SRR1642941.fastq.gz Fastqsanger.gz
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Publications

Next generation sequencing reveals microRNA isoforms in liver cirrhosis and hepatocellular carcinoma.

Wojcicka Anna A   Swierniak Michal M   Kornasiewicz Oskar O   Gierlikowski Wojciech W   Maciag Monika M   Kolanowska Monika M   Kotlarek Marta M   Gornicka Barbara B   Koperski Lukasz L   Niewinski Grzegorz G   Krawczyk Marek M   Jazdzewski Krystian K  

The international journal of biochemistry & cell biology 20140527


Hepatocellular carcinoma (HCC) represents the major histological subtype of liver cancer. Tumorigenic changes in hepatic cells potentially result from aberrant expression of microRNAs (miRNAs). Individual microRNA gene may give rise to miRNAs of different length, named isomiRNAs that proved to be functionally relevant. Since microRNA length heterogeneity in hepatic tissue has not been described before, we employed next-generation sequencing to comprehensively analyze microRNA transcriptome in HC  ...[more]

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