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ABSTRACT: The LSD1/KDM1A neuro-specific isoform regulates neuronal differentiation through H3K9 demethylation



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A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation.

Laurent Benoit B   Ruitu Lv L   Murn Jernej J   Hempel Kristina K   Ferrao Ryan R   Xiang Yang Y   Liu Shichong S   Garcia Benjamin A BA   Wu Hao H   Wu Feizhen F   Steen Hanno H   Shi Yang Y  

Molecular cell 20150212 6

Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively. The molecular mechanism that underlies this dual substrate specificity has remained unknown. Here we report that an isoform of LSD1, LSD1+8a, does not have the intrinsic capability to demethylate H3K4me2. Instead, LSD1+8a mediates H3K9me2 demethylation in collaboration with supervillin (SVIL), a new LSD1+8a interacting protein. LSD  ...[more]

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