Dataset Information


Homo sapiens

ABSTRACT: miRNA expression of extracellular vesicles

ORGANISM(S): Homo sapiens  



altmetric image


Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Tominaga Naoomi N   Kosaka Nobuyoshi N   Ono Makiko M   Katsuda Takeshi T   Yoshioka Yusuke Y   Tamura Kenji K   Lötvall Jan J   Nakagama Hitoshi H   Ochiya Takahiro T  

Nature communications 20150401

Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the molecular mechanism behind the passage through this natural barrier remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators of cell-cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB. Importantly, miR-181c promotes the destr  ...[more]

Similar Datasets

2014-08-06 | E-GEOD-58734 | ArrayExpress
2018-09-01 | GSE117744 | GEO
| GSE107985 | GEO
| GSE111478 | GEO
2015-04-02 | E-GEOD-63445 | ArrayExpress
2015-04-02 | E-GEOD-63447 | ArrayExpress
| GSE63445 | GEO
2010-09-25 | GSE24338 | GEO
2010-09-25 | E-GEOD-24338 | ArrayExpress
| PRJNA317999 | ENA