Genomics

Dataset Information

118

Saccharomyces cerevisiae


ABSTRACT: RNA processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

ORGANISM(S): Saccharomyces cerevisiae  

PROVIDER: PRJNA267766 | ENA |

REPOSITORIES: ENA

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Publications

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

Manfrini Nicola N   Trovesi Camilla C   Wery Maxime M   Martina Marina M   Cesena Daniele D   Descrimes Marc M   Morillon Antonin A   d'Adda di Fagagna Fabrizio F   Longhese Maria Pia MP  

EMBO reports 20141219 2


Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indicate that RNA-processing factors play critical, yet poorly understood, roles in genomic stability. Here, we provide evidence that the Saccharomyces cerevisiae RNA decay factors Xrn1, Rrp6 and Trf4 reg  ...[more]

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