Genomics

Dataset Information

59

Macaca fascicularis


ABSTRACT: mRNA expression of brain endothelial cells

ORGANISM(S): Macaca fascicularis  

PROVIDER: PRJNA267768 | ENA |

REPOSITORIES: ENA

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Publications

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Tominaga Naoomi N   Kosaka Nobuyoshi N   Ono Makiko M   Katsuda Takeshi T   Yoshioka Yusuke Y   Tamura Kenji K   Lötvall Jan J   Nakagama Hitoshi H   Ochiya Takahiro T  

Nature communications 20150401


Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the molecular mechanism behind the passage through this natural barrier remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators of cell-cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB. Importantly, miR-181c promotes the destr  ...[more]

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