Caenorhabditis elegans
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA267831 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Transcriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL RNA-Seq)
| PRJNA239338 | ENA
Project description:Transcriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL small RNA)
| PRJNA239337 | ENA
Project description:Transcriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL PAR-CLIP)
| PRJNA239325 | ENA
Project description:A variety of Dicer substrates in human and C. elegans (HEK RNA-seq)
| PRJNA268010 | ENA
Project description:CEL-Seq transcriptomic analysis of C. elegans blastomeres
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Project description:Dietary restriction (DR) is the most effective and reproducible intervention to extend lifespan in divergent species1. In mammals, two regimens of DR, intermittent fasting (IF) and caloric restriction (CR), have proven to extend lifespan and reduce the incidence of age-related disorders2. An important characteristic of IF is that it can increase lifespan, even when there is little or no overall decrease in calorie intake2. The molecular mechanisms underlying IF-induced longevity, however, remain largely unknown. Here we establish an IF regimen that effectively extends the lifespan of Caenorhabditis elegans, and show that a nutrient-related signalling molecule, the low molecular weight GTPase Cel-Rheb, has a dual role in lifespan regulation; Cel-Rheb is required for the IF-induced longevity, whereas inhibition of Cel-Rheb mimics the CR effects. We also show that Cel-Rheb exerts its effects in part via the insulin/IGF-like signalling effector DAF-16 in IF, and that Cel-Rheb is required for fasting-induced nuclear translocation of DAF-16. We find that HSP-12.6, a DAF-16 target, functions to mediate the IF-induced longevity. Furthermore, our analyses demonstrate that most of fasting-induced upregulated genes require Cel-Rheb function for their induction, and that Cel-Rheb/Cel-TOR signalling is required for the fasting-induced downregulation of an insulin-like peptide, INS-7. These findings identify the essential role of signalling via Cel-Rheb in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway.
2008-12-15 | GSE9682 | GEO
Project description:A variety of Dicer substrates in human and C. elegans (HEK PAR-CLIP)
| PRJNA267836 | ENA
Project description:A variety of Dicer substrates in human and C. elegans (HEK small RNA)
| PRJNA267838 | ENA
Project description:Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer
| PRJNA132317 | ENA