Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Human embryonic stem cell based neuro-developmental toxicity assay: response to valproic acid and carbamazepine exposure

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA270221 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.

Schulpen Sjors H W SH   Pennings Jeroen L A JL   Piersma Aldert H AH  

Toxicological sciences : an official journal of the Society of Toxicology 20150515 2


Differentiating pluripotent stem cells in vitro have proven useful for the study of developmental toxicity. Here, we studied the effects of anticonvulsant drug exposure in a human embryonic stem cell (hESC)-based neurodevelopmental toxicity test (hESTn). During neural differentiation the cells were exposed, for either 1 or 7 days, to noncytotoxic concentration ranges of valproic acid (VPA) or carbamazepine (CBZ), antiepileptic drugs known to cause neurodevelopmental toxicity. The effects observe  ...[more]

Similar Datasets

| GSE64123 | GEO
2020-01-01 | S-EPMC7603451 | BioStudies
1000-01-01 | S-EPMC3440079 | BioStudies
| GSE71127 | GEO
2015-01-01 | S-EPMC4669700 | BioStudies
2016-01-01 | S-EPMC4867143 | BioStudies
2014-01-01 | S-EPMC4172731 | BioStudies
2013-01-01 | S-EPMC3895482 | BioStudies
2016-01-01 | S-EPMC4927565 | BioStudies
1000-01-01 | S-EPMC4710658 | BioStudies