Dataset Information


Homo sapiens

ABSTRACT: Human embryonic stem cell based neuro-developmental toxicity assay: response to valproic acid and carbamazepine exposure

ORGANISM(S): Homo sapiens  



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Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.

Schulpen Sjors H W SH   Pennings Jeroen L A JL   Piersma Aldert H AH  

Toxicological sciences : an official journal of the Society of Toxicology 20150515 2

Differentiating pluripotent stem cells in vitro have proven useful for the study of developmental toxicity. Here, we studied the effects of anticonvulsant drug exposure in a human embryonic stem cell (hESC)-based neurodevelopmental toxicity test (hESTn). During neural differentiation the cells were exposed, for either 1 or 7 days, to noncytotoxic concentration ranges of valproic acid (VPA) or carbamazepine (CBZ), antiepileptic drugs known to cause neurodevelopmental toxicity. The effects observe  ...[more]

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