Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Cellular adhesion promotes prostate cancer cells escape from dormancy

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA270547 | ENA |

REPOSITORIES: ENA

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Publications


Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Identifying mechanisms of PCa dormancy and reactivation remain a challenge partly due to the lack of in vitro models. Here, we characterized in vitro PCa dormancy-reactivation by inducing cells from three patient-derived xenograft (P  ...[more]

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