Dataset Information


Mus musculus

ABSTRACT: H3K27 trimethylation in mouse peripheral nerve

ORGANISM(S): Mus musculus  



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Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2.

Ma Ki H KH   Hung Holly A HA   Srinivasan Rajini R   Xie Huafeng H   Orkin Stuart H SH   Svaren John J  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20150601 22

Myelination of peripheral nerves by Schwann cells requires coordinate regulation of gene repression as well as gene activation. Several chromatin remodeling pathways critical for peripheral nerve myelination have been identified, but the functions of histone methylation in the peripheral nerve have not been elucidated. To determine the role of histone H3 Lys27 methylation, we have generated mice with a Schwann cell-specific knock-out of Eed, which is an essential subunit of the polycomb repressi  ...[more]

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