Dataset Information


Mus musculus

ABSTRACT: Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet

ORGANISM(S): Mus musculus  



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Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet.

Liu Xiaoying X   Henkel Anne S AS   LeCuyer Brian E BE   Schipma Matthew J MJ   Anderson Kristy A KA   Green Richard M RM  

American journal of physiology. Gastrointestinal and liver physiology 20151015 12

Fatty liver is associated with endoplasmic reticulum stress and activation of the hepatic unfolded protein response (UPR). Reduced hepatic expression of the UPR regulator X-box binding protein 1 spliced (XBP1s) is associated with human nonalcoholic steatohepatitis (NASH), and feeding mice a high-fat diet with fructose/sucrose causes progressive, fibrosing steatohepatitis. This study examines the role of XBP1 in nonalcoholic fatty liver injury and fatty acid-induced cell injury. Hepatocyte-specif  ...[more]

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