Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Transcriptome analysis of TNFR2-knockout mouse colon

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA273889 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR1777612_1.fastq.gz Fastqsanger.gz
SRR1777612_2.fastq.gz Fastqsanger.gz
SRR1777613_1.fastq.gz Fastqsanger.gz
SRR1777613_2.fastq.gz Fastqsanger.gz
SRR1777614_1.fastq.gz Fastqsanger.gz
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Publications

Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8(+) T Cells in Mice With Colitis.

Punit Shivesh S   Dubé Philip E PE   Liu Cambrian Y CY   Girish Nandini N   Washington M Kay MK   Polk D Brent DB  

Gastroenterology 20150611 4


<h4>Background & aims</h4>Tumor necrosis factor receptor 2 (TNFR2, Tnfrsf1b) regulates multiple aspects of immune function, but little is known about its role in the immunopathogenesis of inflammatory bowel disease (IBD). We investigated whether TNFR2 restricts the activity of specific immune cell subtypes to protect against the development of colitis in mice.<h4>Methods</h4>Tnfr2(-/-) mice were crossed with interleukin (Il) 10(-/-) mice, which spontaneously develop colitis, to generate Il10(-/-  ...[more]

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