Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA273981 | ENA |

REPOSITORIES: ENA

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Publications

Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia.

Li Yizhen Y   Wang Huanwei H   Wang Xiaoling X   Jin Wen W   Tan Yun Y   Fang Hai H   Chen Saijuan S   Chen Zhu Z   Wang Kankan K  

Blood 20151106 2


The AML1/ETO fusion protein is essential to the development of t(8;21) acute myeloid leukemia (AML) and is well recognized for its dominant-negative effect on the coexisting wild-type protein AML1. However, the genome-wide interplay between AML1/ETO and wild-type AML1 remains elusive in the leukemogenesis of t(8;21) AML. Through chromatin immunoprecipitation sequencing and computational analysis, followed by a series of experimental validations, we report here that wild-type AML1 is able to orch  ...[more]

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