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ABSTRACT: MiR-30e in Aortic Smooth Muscle Cells and Bone Marrow Mesenchymal Stem Cells



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miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice.

Ding Wen W   Li Jihe J   Singh Jayanti J   Alif Razan R   Vazquez-Padron Roberto I RI   Gomes Samirah A SA   Hare Joshua M JM   Shehadeh Lina A LA  

Cardiovascular research 20150212 1

Activation of an osteogenic transcriptional program contributes to the initiation of aortic calcification in atherosclerosis. The role of microRNAs in regulating aortic calcification is understudied. We tested the hypothesis that miR-30e regulates an osteogenic program in bone marrow-derived mesenchymal stem cells (MSCs), aortic smooth muscle cells (SMCs), and ApoE(-/-) mice.In aortas of wild-type mice, we found that miR-30e is highly expressed in medial SMCs. In aortas of old ApoE(-/-) mice, we  ...[more]

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