Dataset Information


Homo sapiens

ABSTRACT: Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas express self polyreactive B cell receptors



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Chlamydophila psittaci-negative ocular adnexal marginal zone lymphomas express self polyreactive B-cell receptors.

Zhu D D   Bhatt S S   Lu X X   Guo F F   Veelken H H   Hsu D K DK   Liu F-T FT   Alvarez Cubela S S   Kunkalla K K   Vega F F   Chapman-Fredricks J R JR   Lossos I S IS  

Leukemia 20150213 7

The pathogenesis of Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas (OAEMZLs) is poorly understood. OAEMZLs are monoclonal tumors expressing a biased repertoire of mutated surface immunoglobulins. Antigenic activation of the B-cell receptor (BCR) may have a role in the pathogenesis of these lymphomas. We have analyzed the reactivity of recombinant OAEMZL immunoglobulins. OAEMZL antibodies reacted with self-human antigens, as demonstrated by enzyme-linked immunos  ...[more]

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