Genomics

Dataset Information

353


ABSTRACT: Physical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution

PROVIDER: PRJNA274127 | ENA |

REPOSITORIES: ENA

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Publications


Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in dermal fibroblasts is sufficient for CAF activation and ensuing keratinocyte-derived tumours. We report that CSL silencing induces senescence of primary fibroblasts from dermis, oral mucosa, breast and lung. CSL functions in these cells as a di  ...[more]

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