Dataset Information


Homo sapiens

ABSTRACT: Gene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib

ORGANISM(S): Homo sapiens  



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BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts.

Locatelli S L SL   Cleris L L   Stirparo G G GG   Tartari S S   Saba E E   Pierdominici M M   Malorni W W   Carbone A A   Anichini A A   Carlo-Stella C C  

Leukemia 20140224 9

Relapsed/refractory Hodgkin's lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a synergistic inhibition of cell growth (range, 70-80%) and a marked increase in cell death (up to 96%) due to increased H3 and H4 acetylation and strong mitochondrial injury. Gene expression profilin  ...[more]

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