Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA274139 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts.

Locatelli S L SL   Cleris L L   Stirparo G G GG   Tartari S S   Saba E E   Pierdominici M M   Malorni W W   Carbone A A   Anichini A A   Carlo-Stella C C  

Leukemia 20140224 9


Relapsed/refractory Hodgkin's lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a synergistic inhibition of cell growth (range, 70-80%) and a marked increase in cell death (up to 96%) due to increased H3 and H4 acetylation and strong mitochondrial injury. Gene expression profilin  ...[more]

Similar Datasets

2015-03-01 | E-GEOD-65483 | ArrayExpress
| GSE65479 | GEO
2015-03-01 | E-GEOD-65479 | ArrayExpress
| GSE31059 | GEO
2015-01-29 | E-GEOD-31059 | ArrayExpress
2015-01-29 | E-GEOD-31058 | ArrayExpress
2015-01-29 | E-GEOD-31057 | ArrayExpress
| PRJNA274135 | ENA
| PRJNA154645 | ENA
| PRJNA154647 | ENA