Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: Human Embryo Single Cell Transcriptome Analysis

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA274140 | ENA |

REPOSITORIES: ENA

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Publications

Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization.

Yanez Livia Z LZ   Han Jinnuo J   Behr Barry B BB   Pera Renee A Reijo RAR   Camarillo David B DB  

Nature communications 20160224


The causes of embryonic arrest during pre-implantation development are poorly understood. Attempts to correlate patterns of oocyte gene expression with successful embryo development have been hampered by the lack of reliable and nondestructive predictors of viability at such an early stage. Here we report that zygote viscoelastic properties can predict blastocyst formation in humans and mice within hours after fertilization, with >90% precision, 95% specificity and 75% sensitivity. We demonstrat  ...[more]

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