Dataset Information


Mus musculus

ABSTRACT: Genome-wide analysis of gene expression in mouse pancreas tumors

ORGANISM(S): Mus musculus  



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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

Zheng Xiaofeng X   Carstens Julienne L JL   Kim Jiha J   Scheible Matthew M   Kaye Judith J   Sugimoto Hikaru H   Wu Chia-Chin CC   LeBleu Valerie S VS   Kalluri Raghu R  

Nature 20151111 7579

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis despite current best therapies; therefore new treatment strategies are urgently required. Numerous studies have suggested that epithelial-to-mesenchymal transition (EMT) contributes to early-stage dissemination of cancer cells and is pivotal for invasion and metastasis of PDAC. EMT is associated with phenotypic conversion of epithelial cells into mesenchymal-like cells in cell culture conditions, although  ...[more]

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