Dataset Information


Homo sapiens

ABSTRACT: Retinoid X Receptor activation reverses the age-related deficiency in myelin debris phagocytosis and enhances remyelination

ORGANISM(S): Homo sapiens  



altmetric image


Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Natrajan Muktha S MS   de la Fuente Alerie G AG   Crawford Abbe H AH   Linehan Eimear E   Nuñez Vanessa V   Johnson Kory R KR   Wu Tianxia T   Fitzgerald Denise C DC   Ricote Mercedes M   Bielekova Bibiana B   Franklin Robin J M RJ  

Brain : a journal of neurology 20151012 Pt 12

The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study, we show that expression of genes involved in the retinoid X receptor pathway are decreased with ageing in both myelin-phagocytosing human monocytes and mouse macrophages using a combination of in vivo and in vitro approaches. Disruption of  ...[more]

Similar Datasets

2015-11-04 | E-GEOD-66988 | ArrayExpress
| GSE66988 | GEO
| GSE93160 | GEO
| GSE93159 | GEO
2010-10-22 | E-GEOD-24821 | ArrayExpress
2010-10-22 | GSE24821 | GEO
| GSE90711 | GEO
| PRJNA208747 | ENA
2009-12-10 | E-GEOD-19403 | ArrayExpress
2015-07-06 | E-GEOD-70475 | ArrayExpress